and:F – Curriculum Vitae

Curriculum Vitae

Andreas Förster, Ph.D.
Imperial College London Division of Molecular Biosciences South Kensington Campus London SW7 2AZ, UK	Telephone: +44.20.7954.3058 Telefax: +44.20.7954.3057 Email: a.forster__AT__imperial.ac.uk Web: www.andf.de/index_e.php

Current Employment
since Aug 2007	Research Associate at Imperial College London, UK – Investigation of the structure and mechanism of action of the AAA-ATPase p97 and its adaptor proteins – Training of postgraduate students on the bench, in lectures and tutorials – Training of users of dynamic light scattering and quantitative PCR instruments – Assistance with x-ray data collection and analysis – Webmaster and maintainer of laboratory wiki and resource database
Scientific Skills
– Production of megadalton protein complexes and membrane proteins: cloning, expression, purification, crystallization – Biophysical characterization of proteins: analytical ultracentrifugation, dynamic light scattering, circular dichroism, differential scanning fluorimetry – Controlled synthesis of physiologically linked oligo-ubiquitin chains – X-ray data collection, structure resolution and analysis: Denzo, XDS, CCP4, CNS, Phaser, Coot, PyMOL – Molecular dynamics and molecular modeling: Rosetta and NAMD2
Additional Skills
– System administration: Linux, Windows XP, Mac OSX – Database administration and web design and creation – Scripting: bash, perl, php, python – Basic understanding of European patent and intellectual property law – Languages: fluent English, German, French; some Spanish
Previous Employment
2005-2007	Structural Biochemist at the Institut de Biologie Structurale, Grenoble, France Post-doctoral position supported by a Marie Curie Fellowship Structural studies of bacterial type III secretion Supervision of postgraduate students
1999-2004	Doctoral Student at the University of Utah, Salt Lake City, Utah, USA Research into structure and function of proteasome–activator complexes Webmaster
Qualifications
May 2005	Doctor of Philosophy in Biochemistry, University of Utah, Salt Lake City, Utah, USA Dissertation: Mechanism of Proteasome Stimulation by 11S Activators
May 1997	Vordiplom, Friedrich-Schiller-University, Jena, Germany Undergraduate degree in biochemistry/molecular biology
Scientific Publications
Cecilia Bebeacua, Andreas Förster, Ciarán McKeown, Hemmo Meyer, Xiaodong Zhang, and Paul S. Freemont Distinct conformations of the p97–Ufd1–Npl4 complex revealed by electron cryo-microscopy Proc Natl Acad Sci USA (2012) 109:1098-103 Patrik Kloppsteck, Caroline A. Ewens, Andreas Förster, Xiaodong Zhang, and Paul S. Freemont Regulation of p97 in the Ubiquitin–Proteasome System by the UBX protein-family Biochim Biophys Acta (2012) 1823:125-9 Mikaël Attia, Andreas Förster, Christophe Rachez, and Paul S. Freemont, Philip Avner, and Ute C. Rogner Interaction between Nucleosome Assembly Protein 1-like family members J Mol Biol (2011) 407:647-60 Caroline A. Ewens, Patrik Kloppsteck, Andreas Förster, Xiaodong Zhang, Paul S. Freemont Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97 Biochem Cell Biol (2010) 88:41-8 Andreas Förster, Paul S. Freemont and R. John Mayer AAA proteins and the life process Biochem Soc Trans (2008) 36:59-61 Andreas Förster, Eugene I. Masters, Frank G. Whitby, Howard Robinson, and Christopher P. Hill The 1.9 Å structure of a proteasome–11S activator complex and implications for proteasome–PAN/PA700 interactions Mol Cell (2005) 18:589-99 Eugene I. Masters, Gregory Pratt, Andreas Förster, and Christopher P. Hill Purification and analysis of recombinant 11S activators of the 20S proteasome: Trypanosoma brucei PA26 and human PA28α, PA28β, and PA28γ Methods Enzymol (2005) 398:306-21 Andreas Förster and Christopher P. Hill Proteasome Activators in Protein Degradation, Vol. 2: The Ubiquitin–Proteasome System by R.J. Mayer, A. Ciechanover and M. Rechsteiner (Eds.), Wiley–VCH (2005) Andreas Förster, Frank G. Whitby and Christopher P. Hill The pore of activated 20S proteasomes has an ordered seven-fold symmetric conformation EMBO J (2003) 22:4356-64 Andreas Förster and Christopher P. Hill Proteasome Degradation: Enter the Substrate Trends Cell Biol (2003) 13:550-3
Presentations and Teaching
Andreas Förster Introduction to X-ray Crystallography
2010, 2011	Lecture: M.Sc. students, Imperial College London, UK
Andreas Förster, Mathieu Rappas, Dan Bose, Paul S. Freemont, and Xiaodong Zhang Determination of the Structure of HsfA from Crystals Displaying Lattice Translocation
2009	Poster: 8th International Conference on AAA Proteins, Toronto, Canada
Patrik Kloppsteck and Andreas Förster Optimizing Protein Stability: A Tale of Buffers, Light and Heat
2009	Talk: Centre for Structural Biology Techniques Workshop, Imperial College London, UK
Andreas Förster, Ina Attree and Andrea Dessen Dancing with Detergents: Purification of a Soluble Membrane Protein
2006	Poster: 3rd International Conference on Structure, Dynamics and Function of Proteins in Biological Membranes, Ascona, Switzerland
	Poster: The Structure and Function of Large Molecular Assemblies, 38th Crystallographic Meeting at Erice, Italy
Andreas Förster, Frank G. Whitby, Eugene I. Masters, and Christopher P. Hill Understanding Proteasome Activation – A Structural Approach
2005	Talk: Purdue University, West Lafayette, IN
2004	Talk and Poster: Northwest Crystallography Workshop, Seattle, WA
Andreas Förster, Frank G. Whitby, Eugene I. Masters, and Christopher P. Hill Opening the Gate – A Universal Mechanism for Proteasome Activation
2003	Poster: 5th International Conference on Molecular Structural Biology, Vienna, Austria
	Talk and Poster: 16th West Coast Protein Crystallography Workshop, Pacific Grove, CA
	Talk: Max-Planck-Institute for Molecular Cell Biology and Genetics, Dresden, Germany
	Talk: Friedrich-Schiller-University, Jena, Germany
Professional Development
Mar 2012	Distance learning course "Game Theory" Stanford University, USA
Oct 2010	Visiting Scientist with Dr. Robert E. Cohen Colorado State University, Fort Collins, USA
Oct 2009	National Grid System Innovation Forum London, UK
2006-2007	Distance learning course "Intellectual Property Law" Fernuniversität Hagen, Germany
Apr 2006	Analysis of Analytical Ultracentrifugation Data with Sedfit and Sedphat IBS, Grenoble, France
Oct 2005	EMBO Practical Course on Combination of Electron Microscopy and X-ray Crystallography in Structure Determination CNRS, Gif-sur-Yvette, France
July 2003	ACA Summer School Illinois Institute of Technology, Chicago, Illinois USA
Honors, Awards and Fellowships
2005–2007	Marie-Curie Postdoctoral Fellowship
2005	James W Prahl Memorial Award for Outstanding Contributions by a Graduate Student, University of Utah
2003	University of Utah Graduate Research Supplemental Travel Award
2002–2003	University of Utah Graduate Research Fellowship
2002	Graduate Student Poster Award, University of Utah Bioscience Symposium
1998–1999	Fulbright Scholarship
References
Letters of Reference are available from the following scientists: Prof. Paul S. Freemont Chair of Protein Crystallography Imperial College London Telephone: +44.20.7594.5327 Email: p.freemont__AT__imperial.ac.uk Prof. Xiaodong Zhang Professor of Macromolecular Structure and Function Imperial College London Telephone: +44.20.7594.3151 Email: xiaodong.zhang__AT__imperial.ac.uk Dr. Andrea Dessen Directeur de Recherche Institut de Biologie Structurale Telephone: +33.438.789590 Email: andrea.dessen__AT__ibs.fr Prof. Christopher P. Hill Professor of Biochemistry University of Utah Telephone: +1.801.585.5536 Email: chris__AT__biochem.utah.edu Prof. Wesley I. Sundquist Professor of Biochemistry University of Utah Telephone: +1.801.585.5402 Email: wes__AT__biochem.utah.edu

Curriculum Vitae

Andreas Förster, Ph.D.

Current Employment

Scientific Skills

Additional Skills

Previous Employment

Qualifications

Scientific Publications

Presentations and Teaching

Professional Development

Honors, Awards and Fellowships

References